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Multilayer functional bionic fabricated polycaprolactone based fibrous membranes for osteochondral integrated repair
Yinchun Hu1, Xiangfei Yin2, Huixiu Ding2
1Research Center for Nano-Biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China; Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan 030032, PR China.
This study presents a novel multilayer fibrous membrane for osteochondral defect repair. The biomimetic scaffold demonstrates excellent mechanical properties and biological activity for integrated cartilage and bone regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedic Engineering
Background:
- Osteochondral defects pose significant challenges in orthopedic treatment.
- Current repair strategies often lack integrated solutions for both cartilage and subchondral bone.
- Developing advanced biomaterials is crucial for effective osteochondral regeneration.
Purpose of the Study:
- To fabricate a multilayer, biomimetic fibrous membrane for integrated osteochondral defect repair.
- To combine self-induced crystallization, biomimetic mineralization, and layer-by-layer electrospinning for scaffold construction.
- To create a functional scaffold with distinct layers for cartilage, bone, and transitional repair.
Main Methods:
- Fabrication of a multilayer polycaprolactone (PCL) based fibrous membrane using layer-by-layer electrospinning.
- Encapsulation of glucosamine hydrochloride (GAH) in core-shell PCL fibers (MGPCL) for cartilage repair.
- Creation of shish-kebab (SK) structured PCL fibers with calcium phosphate coating (MSKPCL) for subchondral bone repair.
- Utilizing SK structured MGPCL fibrous membrane (SKMGPCL) as an intermediate layer.
Main Results:
- The fabricated MG/SKMG/MSKPCL fibrous membrane exhibited a tensile modulus of 34.24 ± 2.39 MPa, suitable for both cartilage and subchondral bone repair.
- In vitro studies demonstrated good biological activity of the scaffold.
- The material showed significant osteogenic ability, indicating potential for bone regeneration.
Conclusions:
- The developed multilayer functional bionic fibrous membrane offers a promising material basis for integrated osteochondral repair.
- The biomimetic design effectively addresses the distinct requirements of cartilage and subchondral bone regeneration.
- This innovative scaffold holds potential for advancing orthopedic treatments for complex osteochondral defects.
