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Author Spotlight: Exploring Abdominal VNS for Inflammatory Conditions
Published on: January 19, 2024
Vagus innervation in the gastrointestinal tumor: Current understanding and challenges
Yan-Ting Li1, Wen-Zhen Yuan1, Wei-Lin Jin2
1The First Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China; Department of Surgical Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, PR China.
Abstract:
The vagus nerve (VN) is the main parasympathetic nerve of the autonomic nervous system. It is widely distributed in the gastrointestinal tract and maintains gastrointestinal homeostasis with the sympathetic nerve under physiological conditions. The VN communicates with various components of the tumor microenvironment to positively and dynamically affect the progression of gastrointestinal tumors (GITs). The intervention in vagus innervation delays GIT progression. Developments in adeno-associated virus vectors, nanotechnology, and in vivo neurobiological techniques have enabled the creation of precisely regulated "tumor neurotherapies". The present review aimed to summarize the mechanisms of communication between the VN and the gastrointestinal TME and to explore the potential and challenges of VN-based tumor neurotherapy in GITs.
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