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Updated: Aug 5, 2025
09:19
Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
Published on: July 6, 2022
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Spatially resolved transcriptomics: a comprehensive review of their technological advances, applications, and
Mengnan Cheng1, Yujia Jiang1, Jiangshan Xu1
1BGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Journal of Genetics and Genomics = Yi Chuan Xue Bao
|March 29, 2023
Summary
Spatially Resolved Transcriptomics (SRT) offers unprecedented insights into life's molecular organization. This review covers SRT technologies, bioinformatics, and applications, highlighting its potential for understanding cellular development and diseases.
Area of Science:
- Molecular Biology
- Genomics
- Biotechnology
Background:
- Technological advancements have historically driven biological exploration, from microscopy to single-cell sequencing.
- Spatially Resolved Transcriptomics (SRT) addresses the need to understand molecular organization in 3D space.
- SRT bridges the gap between molecular data and spatial context in biological systems.
Purpose of the Study:
- To review recent technological and bioinformatic advancements in Spatially Resolved Transcriptomics (SRT).
- To discuss current challenges and representative applications of SRT technologies.
- To highlight the future potential of SRT in biological research.
Main Methods:
- Review of Spatially Resolved Transcriptomics technologies.
- Analysis of bioinformatic tools for SRT data.
- Compilation of representative SRT applications in life sciences.
Main Results:
- SRT enables visualization of molecular landscapes at high resolution.
- Technological progress in SRT is rapid, with diverse applications emerging.
- Bioinformatic tools are crucial for interpreting complex SRT data.
Conclusions:
- SRT technologies are revolutionizing the understanding of cellular origins and disease mechanisms.
- The integration of advanced technologies and bioinformatics promises deeper biological insights.
- SRT holds significant potential for future discoveries in fundamental biology and medicine.
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