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Textbook outcome: A novel metric in heart transplantation outcomes
Jason Zakko1, Akash Premkumar2, April J Logan3
1Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Insights
A new metric called textbook outcome, which includes factors like length of stay and 1-year survival, better assesses heart transplant quality. Achieving textbook outcome is linked to improved long-term survival for heart transplant recipients.
Area of Science:
- Cardiology
- Transplantation Medicine
- Health Services Research
Background:
- Assessing heart transplant program quality solely on short-term survival is inadequate.
- A comprehensive metric is needed to evaluate patient outcomes and center performance holistically.
Purpose of the Study:
- To define and validate a composite metric, "textbook outcome," for heart transplantation.
- To examine the association between achieving textbook outcome and overall long-term survival.
Main Methods:
- Analysis of primary, isolated adult heart transplants from the United Network for Organ Sharing/Organ Procurement and Transplantation Network database (2005-2017).
- Textbook outcome defined by specific criteria including length of stay, ejection fraction, functional status, and freedom from adverse events during hospitalization and the first year post-transplant.
- Univariate, multivariate analyses, and nomogram creation to predict textbook outcome; conditional survival measured.
Main Results:
- 11,169 of 24,620 (45.4%) heart transplant recipients achieved textbook outcome.
- Factors associated with textbook outcome included freedom from preoperative mechanical support, dialysis, being nondiabetic, and nonsmoker status.
- Patients achieving textbook outcome demonstrated significantly improved long-term survival (hazard ratio for death 0.547).
Conclusions:
- Textbook outcome serves as a valuable alternative metric for evaluating heart transplant outcomes.
- This composite measure is associated with improved long-term survival, offering a more holistic assessment of patient and center performance.
Objective:
Assessing heart transplant program quality using short-term survival is insufficient. We define and validate the composite metric textbook outcome and examine its association with overall survival.
Methods:
We identified all primary, isolated adult heart transplants in the United Network for Organ Sharing/Organ Procurement and Transplantation Network Standard Transplant Analysis and Research files from May 1, 2005, to December 31, 2017. Textbook outcome was defined as length of stay 30 days or less; ejection fraction greater than 50% during 1-year follow-up; functional status 80% to 100% at 1 year; freedom from acute rejection, dialysis, and stroke during the index hospitalization; and freedom from graft failure, dialysis, rejection, retransplantation, and mortality during the first year post-transplant. Univariate and multivariate analyses were performed. Factors independently associated with textbook outcome were used to create a predictive nomogram. Conditional survival at 1 year was measured.
Results:
A total of 24,620 patients were identified with 11,169 (45.4%, 95% confidence interval, 44.7-46.0) experiencing textbook outcome. Patients with textbook outcome were more likely free from preoperative mechanical support (odds ratio, 3.504, 95% confidence interval, 2.766 to 4.439, P < .001), free from preoperative dialysis (odds ratio, 2.295, 95% confidence interval, 1.868-2.819, P < .001), to be not hospitalized (odds ratio, 1.264, 95% confidence interval, 1.183-1.349, P < .001), to be nondiabetic (odds ratio, 1.187, 95% confidence interval, 1.113-1.266, P < .001), and to be nonsmokers (odds ratio, 1.160, 95% confidence interval,1.097-1.228, P < .001). Patients with textbook outcome have improved long-term survival relative to patients without textbook outcome who survive at least 1 year (hazard ratio for death, 0.547, 95% confidence interval, 0.504-0.593, P < .001).
Conclusions:
Textbook outcome is an alternative means of examining heart transplant outcomes and is associated with long-term survival. The use of textbook outcome as an adjunctive metric provides a holistic view of patient and center outcomes.
