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Related Experiment Videos

Chronically administered morphine increases dopamine receptor sensitivity in mice.

J R Martin, A E Takemori

    European Journal of Pharmacology
    |February 18, 1986
    PubMed
    Summary
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    Chronic morphine use increases dopamine receptor sensitivity in mice. Concurrent lithium administration mitigates this effect and influences analgesic tolerance and withdrawal symptoms.

    Area of Science:

    • Neuropharmacology
    • Opioid Research

    Background:

    • Chronic morphine treatment may induce dopamine receptor supersensitivity.
    • Previous studies relied on post-withdrawal assessments.

    Purpose of the Study:

    • To investigate dopamine receptor changes during continuous chronic morphine exposure.
    • To evaluate the effects of concurrent lithium administration.

    Main Methods:

    • Mice received morphine via implanted pellets.
    • Assessed apomorphine sensitivity and [3H]spiroperidol binding.
    • Administered lithium concurrently with morphine.

    Main Results:

    • Continuous morphine increased sensitivity to apomorphine and dopamine receptor binding sites.

    Related Experiment Videos

  • Lithium attenuated these morphine-induced changes.
  • Lithium enhanced analgesic tolerance and naloxone-induced hypothermia.

    • Conclusions:

    • Chronic morphine induces central dopamine receptor supersensitivity.
    • Lithium modulates these receptor changes and influences morphine's effects on tolerance and withdrawal.