Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

155
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
155
Ultrasonography01:17

Ultrasonography

4.6K
Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Somatostatin receptor PET response assessment framework for patients with neuroendocrine tumours (V1.0): a modified Delphi consensus from the European Neuroendocrine Tumor Society (endorsed by EANM and NANETS).

The Lancet. Oncology·2026
Same author

Real-world outcomes of [<sup>177</sup>Lu]Lu-PSMA-I&T in [<sup>18</sup>F]FDG-positive metastatic castration-resistant prostate cancer: factors related to response and survival.

European journal of nuclear medicine and molecular imaging·2026
Same author

Improving the Somatostatin Receptor Status Assessment for Personalized and Precise Management of Neuroendocrine Neoplasms with the Use of a <sup>99m</sup>Tc-Radiolabeled Somatostatin Receptor Antagonist: The Final Results of the ERA PerMed TECANT Clinical Trial.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Plasma phospho-tau 217 outperforms plasma phospho-tau 181 analyzed with Lumipulse in detecting Alzheimer's dementia in a real-world memory clinic population.

Frontiers in aging neuroscience·2026
Same author

Peptide receptor radionuclide therapy in neuroendocrine tumours: advances, combination strategies, and future directions.

European journal of nuclear medicine and molecular imaging·2026
Same author

Paving the Way for CCK2R-Targeted Peptide Receptor Radionuclide Therapy with [<sup>177</sup>Lu]Lu-DOTA-MGS5 in Patients with Small Cell Lung Cancer.

Pharmaceutics·2026

Related Experiment Video

Updated: Aug 5, 2025

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice
07:38

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

Published on: April 13, 2018

11.5K

Imaging Fibrosis.

Anna Sviridenko1, Gianpaolo di Santo1, Irene Virgolini1

  • 1Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.

PET Clinics
|March 29, 2023
PubMed
Summary
This summary is machine-generated.

Assessing tissue inflammation and fibrosis in vivo is crucial for disease prognosis. A novel 68Ga-fibroblast activation protein inhibitor may enhance noninvasive diagnosis of fibroinflammatory conditions.

Keywords:
(68)Ga-FAPI-46 PET/CTFAPI–Triggered antifibrosis therapiesFibrosisIgG4-related diseasePersisting pulmonary lesions after COVID-19

More Related Videos

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis
06:46

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis

Published on: February 25, 2022

1.9K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.1K

Related Experiment Videos

Last Updated: Aug 5, 2025

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice
07:38

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

Published on: April 13, 2018

11.5K
3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis
06:46

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis

Published on: February 25, 2022

1.9K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.1K

Area of Science:

  • Biomedical imaging
  • Molecular imaging
  • Fibrosis research

Background:

  • Tissue injury in nonmalignant diseases arises from inflammation or fibrosis.
  • Current methods struggle to simultaneously assess these processes in vivo.
  • Noninvasive imaging of fibrosis remains a significant challenge.

Purpose of the Study:

  • To highlight the need for synchronous assessment of inflammation and fibrosis.
  • To introduce a novel imaging agent for fibroinflammatory pathology.
  • To evaluate the potential of 68Ga-fibroblast activation protein inhibitor-46 in clinical diagnostics.

Main Methods:

  • Review of current noninvasive molecular imaging techniques.
  • Discussion of limitations in assessing fibrotic responses.
  • Introduction of 68Ga-fibroblast activation protein inhibitor-46 as a potential diagnostic tool.

Main Results:

  • 18F-fluorodeoxyglucose PET shows inflammatory activity but not fibrosis.
  • 68Ga-fibroblast activation protein inhibitor-46 shows promise for fibrosis assessment.
  • Potential for improved diagnostics in fibroinflammatory diseases.

Conclusions:

  • Synchronous in vivo assessment of inflammation and fibrosis is highly desirable.
  • 68Ga-fibroblast activation protein inhibitor-46 offers a potential solution for noninvasive fibrosis imaging.
  • This agent may improve clinical diagnosis for patients with fibroinflammatory conditions and long-term sequelae, such as post-COVID-19 abnormalities.