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Related Experiment Video

Updated: Aug 5, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Autoinflammatory diseases and the kidney.

Mohamed Tharwat Hegazy1,2, Ahmed Fayed3, Rossana Nuzzolese4

  • 1Rheumatology and Clinical Immunology Unit, Internal Medicine Department, Cairo University, Cairo, Egypt.

Immunologic Research
|March 29, 2023
PubMed
Summary
This summary is machine-generated.

Autoinflammatory diseases (AIDs) frequently affect the kidneys, causing diverse conditions like amyloidosis and glomerulonephritis. Early screening and targeted therapies, such as IL-1 inhibitors, are crucial for managing kidney involvement in AIDs.

Keywords:
AmyloidosisAutoinflammatory diseases (AIDs)Drug-induced nephrotoxicityInflammasomeInterleukin-1 inhibitorsKidney involvementNephropathy

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Area of Science:

  • Nephrology
  • Immunology
  • Genetics

Background:

  • Systemic inflammation significantly impacts kidney health, particularly in monogenic and multifactorial autoinflammatory diseases (AIDs).
  • Kidney manifestations in AIDs are diverse, ranging from common issues to severe complications requiring transplantation, with varied pathogenetic backgrounds including inflammasome activation and amyloidosis.
  • Specific renal involvements include amyloidosis, IgA nephropathy, various forms of glomerulonephritis (GN), and vascular disorders like thrombosis, particularly in Behcet's disease.

Purpose of the Study:

  • To highlight the spectrum of kidney involvement in autoinflammatory diseases (AIDs).
  • To emphasize the importance of routine renal assessment and early diagnosis in patients with AIDs.
  • To explore the therapeutic potential of IL-1 inhibitors in managing renal complications of AIDs.

Main Methods:

  • Review of literature on kidney involvement in monogenic and multifactorial autoinflammatory diseases.
  • Discussion of diagnostic screening methods including urinalysis, serum creatinine, proteinuria, microhematuria, and imaging.
  • Exploration of pathogenetic mechanisms and therapeutic strategies, focusing on IL-1 inhibition.

Main Results:

  • Kidney involvement in AIDs presents heterogeneously, including amyloidosis, IgA nephropathy, and various glomerulonephritis types.
  • Routine screening for renal dysfunction is recommended for all patients with AIDs.
  • IL-1 inhibitors show promise in managing kidney disease and improving outcomes in AIDs patients.

Conclusions:

  • Kidney disease is a significant concern in autoinflammatory diseases (AIDs), necessitating vigilant monitoring and management.
  • Early detection through comprehensive screening and awareness of potential complications are vital for patient care.
  • Targeting IL-1 represents a promising therapeutic avenue for improving renal outcomes in AIDs.