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Related Concept Videos

Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

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Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
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Glucose Transporters01:27

Glucose Transporters

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Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
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Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
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Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

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Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
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Glucose Absorption Into the Small Intestine01:26

Glucose Absorption Into the Small Intestine

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Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
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Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

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Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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A Federated Learning-Inspired Evolutionary Algorithm: Application to Glucose Prediction.

Ivanoe De Falco1, Antonio Della Cioppa1,2, Tomas Koutny3

  • 1ICAR-National Research Council of Italy, Via P. Castellino, 80131 Naples, Italy.

Sensors (Basel, Switzerland)
|March 30, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces a novel evolutionary framework for Federated Learning, enhancing data privacy and model interpretability. The approach effectively forecasts glucose levels for diabetic patients, outperforming methods without knowledge sharing.

Keywords:
diabetesevolutionary algorithmsfederated learninginterpretable machine learning

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Area of Science:

  • Machine Learning
  • Artificial Intelligence
  • Computational Biology

Background:

  • Federated Learning (FL) frameworks often struggle with data privacy and solution interpretability.
  • Existing FL approaches may not efficiently address both privacy and interpretability simultaneously.
  • The medical domain, particularly diabetes management, requires robust solutions for data privacy and interpretable predictions.

Purpose of the Study:

  • To propose an innovative Federated Learning-inspired evolutionary framework.
  • To directly employ an Evolutionary Algorithm (EA) for Federated Learning tasks.
  • To simultaneously address data privacy and solution interpretability in Machine Learning.

Main Methods:

  • A master/slave approach where slaves hold local data and use EAs to generate prediction models.
  • The master aggregates locally learned models from slaves to form global models.
  • Utilizing Grammatical Evolution for forecasting future glucose values in diabetic patients.

Main Results:

  • The proposed framework demonstrates superior performance compared to approaches without local model exchange.
  • Knowledge sharing through local models leads to improved generalization capabilities.
  • Performance improvements include ~3.03% precision, 1.56% recall, 3.17% F1-score, and 1.56% accuracy.

Conclusions:

  • The evolutionary framework effectively enhances data privacy and model interpretability in Federated Learning.
  • The knowledge-sharing process is validated for developing personal diabetes management models.
  • The proposed method shows statistically superior performance and generalization capability.