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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

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Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
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Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

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Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
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Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
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Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

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Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Recent Developments in Mpox Prevention and Treatment Options.

Shiza Malik1, Tahir Ahmad2, Omar Ahsan3

  • 1Bridging Health Foundation, Rawalpindi, Punjab 46000, Pakistan.

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Summary

Human mpox, caused by monkeypox virus (MPXV), is a growing global epidemic. This review details emerging vaccines and antivirals for mpox prevention and treatment, highlighting areas for improved efficacy.

Keywords:
MPXVantiviral agentsclinical managementmpoxnovel therapeutictherapeuticsvaccines

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Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Human mpox (MPXV) is an emerging zoonotic disease, sharing similarities with smallpox.
  • MPXV belongs to the Orthopoxviridae family, necessitating updated information on its management.
  • Global mpox outbreaks require comprehensive data on diagnostics, epidemiology, surveillance, and control.

Purpose of the Study:

  • To review recent scientific advancements in mpox prevention and treatment strategies.
  • To provide an overview of emerging therapeutic options for monkeypox virus infections.

Main Methods:

  • Systematic literature review of recent scientific publications.
  • Data collation on diagnostics, epidemiology, surveillance, and control measures.
  • Evaluation of contemporary vaccines and antiviral agents for mpox treatment potential.

Main Results:

  • Details on mpox prevention strategies are presented.
  • Contemporary vaccines and antiviral agents evaluated for mpox treatment are described.
  • Emerging treatment options show promise for controlling mpox infections.

Conclusions:

  • Current treatment options are crucial for managing widespread mpox.
  • Addressing limitations in existing mpox treatments is vital for large-scale deployment.
  • Preventing mpox from becoming a decade-defining pandemic requires enhanced therapeutic strategies.