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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
A Rare Single Case of COVID-19-Induced Acute Myocarditis and Encephalopathy Presenting Simultaneously
Usman Saeedullah1, Anas M Abbas2, Caitlin Ward2
1Department of Medicine and Biomedical Research Institute, NYU Long Island School of Medicine, 101 Mineola Boulevard, Suite 4-004, Mineola, NY 11501, USA.
Insights
This case highlights severe multisystem symptoms, including myocarditis and encephalitis, following COVID-19 infection, even after vaccination. Prompt medical intervention is crucial to prevent permanent damage from these COVID-19 complications.
Area of Science:
- Neurology
- Cardiology
- Infectious Diseases
Background:
- The COVID-19 pandemic presents diverse neurological and cardiovascular complications.
- Myocarditis and encephalitis are serious, potentially fatal, manifestations of SARS-CoV-2 infection.
Observation:
- A vaccinated middle-aged female presented with altered mental status, not typical cardiac symptoms.
- Initial presentation masked the underlying severe multisystem inflammatory syndrome.
Findings:
- The patient was diagnosed with concomitant myocarditis and encephalopathy.
- This represents the first reported case following a COVID-19 booster vaccine.
Implications:
- Early diagnosis and treatment are vital for managing COVID-19-associated myocarditis and encephalopathy.
- Vaccination may not prevent all severe outcomes, underscoring the need for continued vigilance.
- This case emphasizes the potential for severe neurological and cardiac sequelae post-COVID-19.
Abstract:
The ongoing coronavirus disease 2019 (COVID-19) pandemic may result in cardiovascular complications such as myocarditis, while encephalitis is a potentially life-threatening COVID-19-associated central nervous system complication. This case illustrates the possibility of developing severe multisystem symptoms from a COVID-19 infection, despite having received the COVID-19 vaccine within the year. Delay in treatment for myocarditis and encephalopathy can lead to permanent and possibly fatal damage. Our patient, a middle-aged female with a complicated medical history, initially came in without characteristic manifestations of myocarditis such as shortness of breath, chest pain, or arrhythmia, but with an altered mental status. Through further laboratory tests, the patient was diagnosed with myocarditis and encephalopathy, which were resolved within weeks through medical management and physical/occupational therapy. This case presentation describes the first reported case of concomitant COVID-19 myocarditis and encephalitis after receiving a booster dose within the year.
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