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Therapeutic Potential of Luteolin on Cancer
Melisa Çetinkaya1, Yusuf Baran1
1Department of Molecular Biology and Genetics, Faculty of Science, İzmir Institute of Technology, İzmir 35430, Turkey.
Vaccines
|March 30, 2023
Summary
Luteolin, a plant-derived flavonoid, shows promise as a less toxic cancer therapy by targeting tumor growth pathways. Research explores its molecular targets, combination therapies, and nanodelivery for various cancers.
Area of Science:
- Oncology
- Pharmacology
- Natural Product Chemistry
Background:
- Cancer incidence is rising globally, necessitating less toxic therapeutic alternatives to conventional chemotherapy.
- Flavonoids, natural plant compounds, are investigated for their anticancer potential.
- Luteolin, a specific flavonoid, exhibits diverse biological activities, including anticancer properties.
Purpose of the Study:
- To review the molecular mechanisms of Luteolin's anticancer effects.
- To explore combination therapy strategies involving Luteolin.
- To discuss nanodelivery systems for enhancing Luteolin's efficacy in cancer treatment.
Main Methods:
- Literature review of studies on Luteolin's anticancer properties.
- Analysis of Luteolin's interactions with molecular targets and signaling pathways.
- Examination of combination therapies and nanodelivery strategies.
Main Results:
- Luteolin inhibits tumor growth by impacting apoptosis, angiogenesis, migration, and cell cycle progression.
- Its anticancer effects are mediated through interactions with various signaling pathways and proteins.
- The review covers Luteolin's molecular targets, combination therapies, and nanodelivery approaches.
Conclusions:
- Luteolin presents a promising, less toxic alternative or adjunct for cancer therapy.
- Further research into its molecular targets and delivery systems can optimize its clinical application.
- Combination strategies and nanodelivery enhance Luteolin's therapeutic potential against various cancers.
Keywords:
Luteolinangiogenesisanticancerapoptosiscell cycle regulationcombination therapyflavonoidsmetastasismiRNAsnanodelivery systemsMore Related Videos
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