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Updated: Aug 5, 2025
06:05
Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx
Published on: May 2, 2025
525
Advanced Glycation End Products and Psoriasis.
Martina Maurelli1, Paolo Gisondi1, Giampiero Girolomoni1
1Section of Dermatology and Venereology, Department of Medicine, University of Verona, 37126 Verona, Italy.
Vaccines
|March 30, 2023
Summary
Advanced glycation end products (AGEs) accumulate in skin conditions like psoriasis, particularly when linked to metabolic disorders. AGEs trigger inflammatory pathways, suggesting they are key players in disease development and potential therapeutic targets.
Area of Science:
- Biochemistry
- Dermatology
- Immunology
Background:
- Advanced glycation end products (AGEs) are formed through physiological reactions, accumulating with age and in metabolic/inflammatory diseases.
- AGE accumulation is accelerated in conditions like type 2 diabetes, obesity, cardiovascular disease, chronic renal insufficiency, non-alcoholic fatty liver disease, and psoriasis.
- These conditions share intimate associations with psoriasis, highlighting a potential common pathway.
Purpose of the Study:
- To review current evidence on the role of AGEs in the pathogenesis of psoriasis.
- To explore the link between AGEs, inflammation, and metabolic diseases in the context of psoriasis.
Main Methods:
- This study is a narrative review.
- It synthesizes existing scientific literature on AGEs and psoriasis.
Main Results:
- AGEs interact with their receptors (RAGEs), initiating signaling cascades.
- This interaction leads to reactive oxygen species formation and NF-kB activation, key drivers of inflammation and oxidative stress.
- AGEs are implicated in the intersection of inflammatory and metabolic diseases relevant to psoriasis.
Conclusions:
- AGEs may play a significant pathogenic role in psoriasis, especially when co-occurring with metabolic disorders.
- AGEs show potential as biomarkers for inflammation.
- Targeting AGEs could offer novel therapeutic strategies for psoriasis and related conditions.
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