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Related Experiment Video

Updated: Aug 5, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Epstein-Barr Virus History and Pathogenesis.

Hui Yu^1,2, Erle S Robertson²

¹Department of Hematology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China.

|March 30, 2023

Summary

Epstein-Barr virus (EBV), an oncogenic virus, causes lifelong infections and various diseases. Research continues to explore its role in cancer and B lymphocyte transformation.

Keywords:

Epstein-Barr virus cancer induction epithelial carcinoma lymphoma pathogenesis

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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

Area of Science:

Virology
Oncology
Immunology

Background:

Epstein-Barr virus (EBV) is the first identified human oncogenic virus.
EBV establishes asymptomatic, lifelong persistence and is linked to diverse diseases, including lymphoid malignancies and epithelial cancers.
EBV can transform quiescent B lymphocytes into lymphoblastoid cell lines (LCLs) in vitro.

Purpose of the Study:

To review the history and current advances in EBV-associated diseases.
To highlight EBV's role in oncogenesis and non-malignant disorders.
To explore EBV's mechanism of viral-mediated transformation and its precise role in disease promotion.

Main Methods:

Literature review of EBV research over the past 60 years.
Analysis of studies on EBV's interplay with the host during oncogenesis.
Examination of EBV's role in both malignant and non-malignant disorders.

Main Results:

EBV is a significant human oncogenic virus with a broad disease spectrum.
Understanding EBV's host interactions provides insights into oncogenesis.
The precise mechanisms of EBV-mediated transformation and disease promotion require further exploration.

Conclusions:

EBV remains a critical area of research in virology and oncology.
Further investigation into EBV's molecular biology is essential for understanding associated diseases.
EBV serves as a model for studying virus-host interactions in cancer development.