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Published on: February 3, 2023
COVID-19 exposure during pregnancy and low birth weight in community development blocks, Purba Bardhaman: A
Arindam De1, Puspendu Biswas2, Soumalya Ray3
1Department of Community Medicine, Burdwan Medical College and Hospital, Purba Bardhaman, West Bengal, India.
Insights
Maternal COVID-19 infection during pregnancy significantly increases the risk of low birth weight (LBW) in newborns. This community-based study in West Bengal highlights the importance of monitoring pregnant individuals with COVID-19.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Neonatal Health
Background:
- COVID-19 exposure during pregnancy is a growing concern for fetal development.
- Limited community-based data exists on the impact of maternal COVID-19 on birth weight in West Bengal.
- Understanding this relationship is crucial for public health interventions.
Purpose of the Study:
- To determine the association between maternal COVID-19 exposure and low birth weight (LBW) in offspring.
- To investigate the risk of LBW among infants born to mothers with COVID-19 during pregnancy.
- To provide community-based evidence from West Bengal.
Main Methods:
- Retrospective cohort study of mothers and children born between February 2020 and October 2021 in Purba Barddhaman district, West Bengal.
- Participants categorized into 'Pregnancy with COVID' and 'Pregnancy without COVID' groups.
- Data collected via antenatal registers; association analyzed using multivariate logistic regression.
Main Results:
- Incidence of LBW was 30.3% in the COVID pregnancy group versus 18.7% in the non-COVID group.
- COVID-19 positivity during pregnancy showed a relative risk of 1.62 for LBW.
- Multivariate analysis confirmed a significant association between maternal COVID-19 and LBW (AOR 2.18), adjusted for confounding factors.
Conclusions:
- COVID-19 positivity during pregnancy is a significant risk factor for delivering a low birth weight baby.
- Findings underscore the need for targeted prenatal care for pregnant individuals with COVID-19.
- This study contributes vital local data on COVID-19's impact on pregnancy outcomes in West Bengal.
Introduction:
COVID-19 exposure during pregnancy is hypothesized to affect the birth weight of the children. Community based findings on such hypothesis are scarce in West Bengal. This study was conducted with the objective to determine the relationship between low birth weight (LBW) and maternal exposure to COVID-19.
Materials And Methods:
In this retrospective cohort study, mothers of children, who were born between February 2020 and October 2021 and who were registered in the subcenters of Purba Barddhaman district, West Bengal, were selected as study population. Mothers who were diagnosed as COVID-19 positive during the antenatal period were considered as 'Pregnancy with COVID' and others were considered as 'Pregnancy without COVID'. The minimum required sample size using Fleiss formula were 119 and 476, respectively, whose were selected through multi-stage random sampling. A schedule was used to collect data through review of relevant records of antenatal registers of sub-centers of selected individuals. The association was checked through multivariate logistic regression model where P < 0.05 was considered statistically significant.
Results:
Incidence of LBW in COVID pregnancy, Non-COVID Pregnancy group were 30.3% and 18.7%, respectively. COVID positivity during pregnancy shows relative risk of 1.62 and attributable risk of 38.28% for LBW baby as pregnancy outcome. Multivariate analysis reveals that LBW babies are significantly associated with COVID status during pregnancy (AOR 2.18, 1.3-3.63) after adjusting for anemia in pregnancy, incomplete antenatal visits, mothers age ≥30 years, parity and periods of gestation.
Conclusion:
The study concludes that COVID positivity during pregnancy significantly increases the risk of LBW as pregnancy outcome.
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