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A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

Sana Ahmed-Seghir, Manisha Jalan, Helen E Grimsley

    Biorxiv : the Preprint Server for Biology
    |March 30, 2023
    PubMed
    Summary

    Researchers found that a single stalled replication fork triggers a localized DNA damage response. This localized management allows DNA replication to continue elsewhere, maintaining genomic integrity without global delays.

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