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195

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling

Jaewoong Lee, Mark E Robinson, Ruifeng Sun

    Biorxiv : the Preprint Server for Biology
    |March 30, 2023
    PubMed
    Summary

    CD25 on B-cells, not as an IL2-receptor, forms an inhibitory complex to control B-cell receptor signaling. This finding impacts understanding of B-cell development, autoimmunity, and B-cell malignancies like leukemia and lymphoma.

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