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Symptom-led staging for primary progressive aphasia.

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Summary

A new staging system for primary progressive aphasias (PPA) was developed using caregiver surveys. This PPA Progression Planning Aid (PPA²) helps predict disease progression and manage daily life impacts.

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Area of Science:

  • Neurology
  • Linguistics
  • Gerontology

Background:

  • Primary progressive aphasias (PPA) present complex diagnostic, management, and prognostic challenges.
  • A clinically-informed, syndromic staging system is needed to address these challenges.

Conclusions:

  • Introduced the PPA Progression Planning Aid (PPA²), a prototypical staging scheme for PPA.
  • Findings support improved diagnostic and care pathways, trial design, and personalized prognosis and treatment for PPA.
  • Functional milestones identified as key predictors of daily life impacts and management needs across PPA syndromes.