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A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
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Tissue-engineered models of lung cancer premalignancy.
Biorxiv : the Preprint Server for Biology
|March 30, 2023
Summary
A new engineered hydrogel model using precision-cut lung slices creates an in vitro lung cancer premalignancy model. This advance enables better study of carcinogenesis and chemoprevention strategies for lung cancer.
Area of Science:
- Biotechnology
- Oncology
- Tissue Engineering
Background:
- Lung cancer is a leading cause of cancer death globally.
- Many diagnoses occur in former smokers, highlighting a need for better research models.
- Current rodent models for lung cancer research are resource-intensive.
Conclusions:
- This engineered hydrogel-based PCLS model provides a viable in vitro system for studying lung cancer premalignancy.
- The model serves as a foundation for developing more advanced ex vivo research tools.
- It offers a promising platform for investigating carcinogenesis and testing novel chemoprevention strategies.
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