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[Are Hegar's rods omissible? (author's transl)]
Geburtshilfe Und Frauenheilkunde
|January 1, 1979
Summary
Sulproston effectively widens the cervix in non-pregnant women, including those postmenopausal. This cervical dilation effect is consistent across different reproductive stages, similar to prostaglandin E2 (PGE2).
Area of Science:
- Reproductive Medicine
- Pharmacology
Background:
- Cervical dilation is crucial for gynecological procedures.
- Prostaglandin E2 (PGE2) and its derivatives are known to induce cervical ripening in pregnant uteri.
Purpose of the Study:
- To investigate the cervical widening effect of Sulproston in non-pregnant women.
- To compare the effect in premenopausal and postmenopausal women.
Main Methods:
- A double-blind study involving 50 non-pregnant volunteers.
- Intramuscular administration of Sulproston (500 micrograms).
- Measurement of cervical dilation using Hegar's rods.
Main Results:
- Sulproston demonstrated significant cervical widening in postmenopausal women (Hegar 8.33 +/- 0.87).
- Easy cervical and internal os passage was noted in the first (Hegar 8.22 +/- 0.66) and second (Hegar 8.35 +/- 3.06) halves of the cycle.
- Cervical dilation was significantly less with a placebo (physiological saline).
Conclusions:
- Sulproston effectively induces cervical dilation in non-pregnant women.
- The cervical widening effect of Sulproston is comparable to PGE2 derivatives, applicable to non-pregnant cyclic and postmenopausal uteri.