Related Experiment Video
Updated: Aug 4, 2025

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Chronic Venous Insufficiency and Lymphedema With Papillomatosis Cutis Lymphostatica, Hyperkeratosis, and Skin Ulcers:
Jayani Senanayake1, Sanket Chaudhari2, Rangin Haji Rahman3
1Internal Medicine, Saint James School of Medicine, Chicago, USA.
Abstract:
Chronic venous insufficiency (CVI) is a common condition characterized by lower extremity edema, discomfort, and skin changes due to venous hypertension caused by incompetent or obstructed venous valves. We report a case of chronic venous insufficiency and lymphedema with papillomatosis cutis lymphostatica, hyperkeratosis, and skin ulcers with proteus superinfection. A 67-year-old male presented to the emergency department (ED) for wound evaluation and was found to have severe hyperkeratosis, multiple ulcers with purulent discharge, and "tree bark" skin changes. Prophylactic treatment for deep vein thrombosis (DVT) was initiated, followed by successful surgical debridement. A subsequent diagnosis of Proteus mirabilis superinfection was treated accordingly. This report highlights the importance of adequate long-term management of chronic venous insufficiency as it may lead to serious complications.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Assessment of the Cardiovascular System III: Palpation
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Venous Thrombosis IV: Nursing Management
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...

