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Updated: Aug 4, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
Computational analysis of a microRNA signature for poor prognosis suggests a microRNA-controlled stemness pathway in
1Department of Immunology, Erasmus MC University Medical Center, Dr. Molewaterpein 40, 3015GD, Rotterdam, The Netherlands.
Abstract:
Esperanza-Cebollada E., et al. found a group of 24 microRNAs, to be differentially expressed between two groups of paediatric acute myeloid leukaemia (AML) cases with distinct outcomes. The main target of this microRNA signature is SOCS2, a gene that controls stemness. The results of this study may open doors for further investigation of the role for microRNAs in poor prognostic paediatric AML. Commentary on: Esperanza-Cebollada et al. A miRNA signature related to stemness identifies high-risk patients in paediatric acute myeloid leukaemia. Br J Haematol 2023;202:96-110.

