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Updated: Aug 4, 2025

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

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Anesthesia and Cancer: Something More than Avoiding Stress Response.

Aida Raigon Ponferrada^1,2,3, Salvador Romero Molina², Juan Carlos Molina Ruiz²

¹Institute of Biomedical Research in Malaga (IBIMA), 29010 Malaga, Spain.

Current Gene Therapy

|March 30, 2023

Summary

Anesthetic drugs can impact cancer progression and patient survival by affecting key cellular pathways. Understanding these interactions is crucial for improving oncological surgery outcomes.

Keywords:

Anesthesia cancer halogenated local anaesthetics miRNAs opioids propofol

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Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

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Published on: October 16, 2013

Area of Science:

Oncology and Anesthesiology
Molecular Biology
Cancer Research

Background:

Increasing tumor pathologies necessitate understanding factors influencing cancer progression.
Anesthetic drugs' impact on patient prognosis and survival is under investigation.
Key cellular signaling pathways like PI3K/AKT/mTOR, EGFR, and Wnt/β-catenin are implicated in carcinogenesis.

Approach:

This review dissects the interaction between anesthetic drugs and cancer cell lines.
Examines effects on cell signaling, genetic, immune, and transcriptomic pathways.
Investigates anesthetic mechanisms influencing hallmarks of cancer progression.

Key Points:

Anesthetic drug choice may influence cancer prognosis and survival.
Specific pathways (PI3K/AKT/mTOR, EGFR, Wnt/β-catenin) are targeted by anesthetics and cancer treatments.
Mechanisms involve genetic, immune, and transcriptomic alterations.

Conclusions:

Clarifying anesthetic drug effects on cancer pathways is essential.
Informed anesthetic selection can potentially improve oncological surgery outcomes.
Further research into anesthetic-cancer interactions is warranted.