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The Effects of Tranexamic Acid in Breast Surgery: A Systematic Review and Meta-Analysis
Minh N Q Huynh1, Chloe R Wong2, Matthew C McRae1
1From the Division of Plastic Surgery.
Plastic and Reconstructive Surgery
|March 30, 2023
Summary
Tranexamic acid (TXA) can reduce hematoma formation in breast surgery. This meta-analysis found TXA to be safe and effective for reducing hematomas, with no significant impact on other postoperative complications.
Area of Science:
- Surgical Oncology
- Anesthesiology
- Plastic Surgery
Background:
- The efficacy of tranexamic acid (TXA) in mitigating blood loss during breast surgery is not well-established.
- This study aimed to evaluate the impact of TXA on postoperative bleeding in breast surgery patients.
Approach:
- A comprehensive meta-analysis was conducted, including seven studies with 1226 patients.
- Searches encompassed major databases (PubMed, Embase, etc.) from inception to April 2020.
- Study quality was assessed using established risk of bias tools.
Key Points:
- TXA administration, whether topical or intravenous, significantly reduced hematoma formation (RR 0.48).
- No significant effects were observed on drain output, seroma rates, or infection rates.
- No adverse events were reported in patients receiving TXA.
Conclusions:
- TXA is a safe and effective option for reducing hematoma rates in breast surgery.
- Evidence suggests TXA's benefit is primarily in hematoma prevention, not other complications.
- Further research may clarify optimal TXA protocols for breast procedures.
