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Bioinspired Mild Photothermal Effect-Reinforced Multifunctional Fiber Scaffolds Promote Bone Regeneration.

Xiaodi Zhang1,2, Qi Li3,4, Longfei Li1

  • 1State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China.

ACS Nano
|March 30, 2023
PubMed
Summary

This study presents a novel scaffold that uses mild photothermal stimulation to enhance bone repair. It effectively recruits mesenchymal stem cells (MSCs), eliminates bacteria, and promotes bone regeneration for tissue engineering applications.

Keywords:
black phosphorusbone regenerationendogenous cells recruitmentmild photothermal therapynanofiber scaffold

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Bone fractures often result in poor healing and infection.
  • Mesenchymal stem cell (MSC) recruitment is crucial for bone repair.
  • Mild thermal stimulation can accelerate chronic disease recovery.

Purpose of the Study:

  • To develop a multifunctional scaffold for bone repair.
  • To utilize a photothermal effect for enhanced bone regeneration.
  • To address challenges of infection and poor healing in bone fractures.

Main Methods:

  • Fabrication of a polycaprolactone nanofiber scaffold doped with black phosphorus nanosheets (BP NSs).
  • Decoration with Apt19S for MSC recruitment and phase change material microparticles for antibacterial drug release.
  • Application of near-infrared (NIR) irradiation for photothermal stimulation.

Main Results:

  • The scaffold demonstrated NIR responsiveness and selective MSC recruitment.
  • Antibacterial drug release was triggered by a phase change material above 39 °C.
  • Photothermal effect promoted MSC osteogenic differentiation and biomineralization, enhancing bone regeneration in vitro and in vivo.

Conclusions:

  • The developed bioinspired scaffold effectively eliminates bacteria, recruits MSCs, and promotes bone regeneration.
  • Mild photothermal stimulation is a promising strategy for bone tissue engineering.
  • This approach offers potential for treating bone fractures with associated infections.