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HIGH-RESOLUTION IMAGING OF THE OUTER RETINA IN TYPE 2 ACUTE MACULAR NEURORETINOPATHY
Nathan Doble1,2, Elaine M Wells-Gray1, Matthew P Ohr2
1The Ohio State University, College of Optometry, 338 W 10th Ave., Columbus, Ohio. Dr. Wells-Gray is now with the Lumata Health, 1111 N. Lee Ave., Suite 210, Oklahoma City; and.
Retinal Cases & Brief Reports
|March 30, 2023
Summary
Adaptive optics imaging revealed that petaloid lesions in type 2 acute macular neuroretinopathy (AMN) result from cone outer segment changes. This finding clarifies the structural basis of visual disturbances in AMN patients.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Photoreceptor Biology
Background:
- Acute macular neuroretinopathy (AMN) is a condition affecting the macula.
- Type 2 AMN presents with characteristic petaloid lesions.
- Understanding the underlying structural changes is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the outer retinal structural changes in a patient with type 2 acute macular neuroretinopathy (AMN).
- To elucidate the role of cone photoreceptors in the pathogenesis of AMN.
Main Methods:
- A case study of a 35-year-old woman with unilateral AMN.
- Utilized advanced retinal imaging techniques: optical coherence tomography (OCT), OCT-angiography, fundus fluorescein angiography, and adaptive optics (AO).
Main Results:
- Fundus examination showed petaloid lesions in the affected eye.
- OCT revealed outer retinal hyperreflectance and disrupted photoreceptor inner/outer segments.
- AO imaging demonstrated shortening or absence of cone outer segments within the lesions.
Conclusions:
- Adaptive optics findings confirm that petaloid lesions in type 2 AMN are due to alterations in cone outer segments.
- These structural changes in cone photoreceptors explain the observed visual symptoms and imaging features.
