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Symptomatic Developmental Venous Anomaly: State-of-the-Art Review on Genetics, Pathophysiology, and Imaging Approach
1From the Division of Neuroradiology (C.C.-T.H.), Department of Medical Imaging, Gold Coast University Hospital, Southport, Queensland, Australia charlie.ct.hsu@gmail.com.
AJNR. American Journal of Neuroradiology
|March 30, 2023
Summary
Developmental venous anomalies (DVAs) are common brain malformations. This review details their genetics and categorization to guide diagnosis and management of symptomatic cases.
Area of Science:
- Neurology
- Radiology
- Genetics
Background:
- Developmental venous anomalies (DVAs) are the most frequent slow-flow cerebral venous malformations.
- While typically benign, DVAs can uncommonly manifest symptomatically, causing diverse pathologies.
- Significant variability exists in DVA size, location, and angioarchitecture.
Purpose of the Study:
- To provide neuroradiologists with a concise overview of symptomatic DVAs.
- To categorize symptomatic DVAs based on underlying pathogenesis.
- To establish a foundation for tailored neuroimaging in diagnosis and management.
Main Methods:
- Review of current literature on DVA genetics and classification.
- Systematic analysis of imaging features associated with symptomatic DVAs.
- Synthesis of pathogenetic information for categorization.
Main Results:
- DVAs exhibit diverse genetic underpinnings and pathogenetic mechanisms.
- A structured categorization of symptomatic DVAs aids in understanding their clinical presentation.
- Imaging findings correlate with specific DVA subtypes and associated risks.
Conclusions:
- Understanding DVA genetics and pathogenesis is crucial for effective neuroimaging.
- A systematic, categorized approach to symptomatic DVAs improves diagnostic accuracy.
- Tailored neuroimaging strategies based on DVA classification enhance patient management.
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