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Platelet function in neonates and children

Suelyn Van Den Helm1, Conor McCafferty1, Natasha Letunica2

  • 1Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.

Thrombosis Research
|March 30, 2023
PubMed

Insights

Platelet function in children is understudied. New methods allow better analysis of platelet roles in neonatal haemostasis and disease.

Area of Science:

  • Hematology
  • Pediatric Medicine
  • Hemostasis and Thrombosis

Background:

  • Platelets are crucial for hemostasis and coagulation, primarily forming stable clots to prevent bleeding.
  • Platelet studies in neonates and children are limited by large blood volume requirements for traditional tests like aggregometry.
  • Developmental changes in platelet function are less understood compared to plasma coagulation factors.

Conclusions:

  • Advances in testing methods are facilitating a better understanding of platelet roles in pediatric hemostasis.
  • Further research is needed to fully elucidate platelet function in neonates and children, particularly in disease states.
  • This review consolidates current knowledge and highlights future research directions in pediatric platelet research.

Keywords:
Blood plateletsChildNewbornPlatelet activationPlatelet aggregationPlatelet function tests

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