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Gut microbiota and neonatal acute kidney injury biomarkers

Kun Yang1,2,3, Guoxia Du1,2,3, Jinjing Liu1,2,3

  • 1Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.

Pediatric Nephrology (Berlin, Germany)
|March 30, 2023
PubMed

Insights

Neonatal acute kidney injury (AKI) is common. This review explores the gut-kidney axis, linking gut microbiota to AKI biomarkers for better prediction and understanding in newborns.

Area of Science:

  • Neonatology
  • Microbiology
  • Nephrology

Background:

  • Acute kidney injury (AKI) is a frequent and serious condition in newborns, impacting hospital stays and mortality.
  • The gut-kidney axis highlights the crucial bidirectional relationship between gut microbiota and kidney health.
  • Current methods for predicting neonatal AKI, such as creatinine and urine output, have limitations.

Purpose of the Study:

  • To review the existing literature on the gut-kidney axis in the context of neonatal AKI.
  • To explore the relationship between gut microbiota and emerging biomarkers for neonatal AKI.
  • To provide novel insights into the gut-kidney axis for improved understanding and prediction of AKI in neonates.

Main Methods:

  • Literature review focusing on the gut-kidney axis.
  • Analysis of studies investigating gut microbiota in neonatal AKI.
  • Examination of novel biomarkers associated with neonatal AKI and their link to gut microbiota.

Main Results:

  • The gut-kidney axis plays a significant role in neonatal health and disease.
  • Gut microbiota composition is increasingly recognized as a factor in AKI development and progression.
  • Emerging biomarkers show potential for improved neonatal AKI prediction, with links to microbial changes.

Conclusions:

  • Understanding the gut-kidney axis is vital for addressing neonatal AKI.
  • Further research into the interplay between gut microbiota and AKI biomarkers can lead to better diagnostic and therapeutic strategies.
  • This review underscores the importance of the gut microbiome in neonatal kidney health.

Keywords:
Acute kidney injuryBiomarkersGut microbiotaGut–kidney axisNeonatal

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