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The correlation between prenatal maternal active smoking and neurodevelopmental disorders in children: a systematic

Danrong Chen1, Qing Niu2, Shiping Liu3

  • 1School of Public Health, Nanjing Medical University, Nanjing, 211166, China.

BMC Public Health
|March 30, 2023
PubMed

Insights

Maternal smoking during pregnancy is linked to a higher risk of neurodevelopmental disorders in children, particularly developmental coordination disorder (DCD). However, no significant association was found with Tourette syndrome (TS).

Area of Science:

  • Neuroscience
  • Pediatrics
  • Public Health

Background:

  • Prenatal exposure to maternal smoking is a significant concern for child neurodevelopment.
  • Existing research has yielded mixed results regarding the association between maternal smoking and specific neurodevelopmental disorders like Tourette syndrome (TS), chronic tic disorder (CTD), and developmental coordination disorder (DCD).

Approach:

  • A systematic meta-analysis was conducted, searching major scientific databases for relevant studies published before August 2021.
  • Eight studies with a total of 50,317 participants were included, employing cohort, case-control, and cross-sectional designs.
  • Pooled effect estimates were calculated to assess the association between maternal active smoking during pregnancy and neurodevelopmental outcomes.

Key Points:

  • Prenatal maternal active smoking is associated with an increased overall risk of neurodevelopmental disorders in children (OR = 1.91).
  • The risk is particularly elevated for developmental coordination disorder (DCD) (OR = 2.25).
  • No significant association was found between maternal active smoking during pregnancy and Tourette syndrome (TS) (OR = 1.07).

Conclusions:

  • This meta-analysis provides evidence for a correlation between maternal active smoking during pregnancy and increased risk of neurodevelopmental disorders in offspring.
  • Developmental coordination disorder (DCD) appears to be significantly associated with prenatal exposure to maternal smoking.
  • Further research is warranted to confirm these findings, considering variations in study methodologies and sample sizes.
Abstract

Keywords:
Active smokingChildrenChronic tic disorderDevelopmental coordination disorderMaternalTourette syndrome

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