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The cholesterol-lowering effect of statins is modified by LILRB5 intolerance genotype: Results from a

Aleksi Tornio1,2,3, Margherita Bigossi3,4, Moneeza K Siddiqui3

  • 1Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.

Frontiers in Pharmacology
|March 31, 2023
PubMed

Insights

The LILRB5 Asp247Gly genotype influences statin response. Individuals with the Asp247Asp genotype showed higher creatine kinase increases and less cholesterol reduction with atorvastatin.

Area of Science:

  • Pharmacogenomics
  • Cardiovascular Medicine
  • Immunology

Background:

  • Statin intolerance leads to poor adherence and adverse cardiovascular outcomes.
  • The LILRB5 Asp247Gly genotype is linked to statin intolerance and myalgia.
  • Understanding genetic influences on statin response is crucial for personalized therapy.

Purpose of the Study:

  • To investigate the role of the LILRB5 Asp247Gly genotype in immune response and cholesterol reduction.
  • To evaluate the impact of this genotype on atorvastatin efficacy and safety.

Main Methods:

  • A double-blind, cross-over, recruit-by-genotype randomized clinical trial.
  • 18 participants with Asp247Asp (T/T) or Gly247Gly (C/C) genotypes received placebo or atorvastatin 80 mg daily for 28 days.
  • Biochemical, immunological, and interview data were collected before and after each treatment period.

Main Results:

  • Individuals with the Asp247Asp genotype had significantly higher creatine kinase increases with atorvastatin compared to Gly247Gly genotype (p=0.03).
  • The Gly247Gly genotype showed greater mean non-HDL cholesterol reduction (2.44 mmol/L) versus Asp247Asp (1.28 mmol/L).
  • Significant interactions between genotype and atorvastatin treatment were observed for total cholesterol (p=0.007) and non-HDL cholesterol response (p=0.025).

Conclusions:

  • The LILRB5 Asp247Gly variant is associated with differential creatine kinase increases and cholesterol-lowering responses to atorvastatin.
  • This genetic variant may have utility in guiding precision cardiovascular therapy.
  • No significant changes in T regulatory cell aggregation were observed based on genotype.
Keywords:
ADR (adverse drug reaction)RCT-randomized controlled trialnon-HDL cholesterolstatin (HMG-CoA reductase inhibitor)treg-regulatory T cell

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