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Updated: Aug 4, 2025
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
Published on: October 17, 2016
Preparation of nanofibrous poly (L-lactic acid) scaffolds using the thermally induced phase separation technique in
Tao Zhang1,2, Kangyao Chen1,2,3, Xing Wu1,2,3
1Department of Orthopedics Institute, Fuzhou Second Hospital of Xiamen University, Fuzhou China.
Abstract:
Porous nanofibrous poly (L-lactic acid) (PLLA) scaffolds were fabricated in combination with a thermally induced phase separation technique using a dioxane/polyethylene glycol (PEG) system. The effect of factors such as molecular weight of PEG, aging treatment, aging or gelation temperature, and the ratio of PEG to dioxane were investigated. The results revealed that all scaffolds had high porosity, and had a significant impact on the formation of nanofibrous structures. The decrease in the molecular weight and aging or gelation temperature leads to a thinner and more uniform fibrous structure.
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