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Do Platelet Count and mean Platelet Volume have a Predictive Role as a Marker in Children with Atopic Dermatitis?
1Department of Pediatrics, Division of Immunology and Allergy Clinic, Istanbul Biruni Univesity Medicine Faculty Hospital, Istanbul, Turkey.
Insights
Platelet counts were significantly higher in children with atopic dermatitis (AD), a common inflammatory skin condition. This study highlights potential platelet biomarkers for AD diagnosis in pediatric patients.
Area of Science:
- Pediatric Allergy and Immunology
- Dermatology
- Hematology
Background:
- Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease affecting 2%-30% of the population, particularly children.
- Platelets are recognized for their role in inflammatory processes.
- Understanding biomarkers for AD is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the potential of platelet count and mean platelet volume (MPV) as biomarkers in pediatric patients diagnosed with atopic dermatitis.
- To compare these hematological parameters between children with AD and healthy controls.
Main Methods:
- A cross-sectional retrospective study design was employed.
- Medical records of 167 children with AD and 170 healthy children were analyzed.
- Data were collected from the Pediatric Allergy and Immunology Outpatient Clinics at Istanbul Biruni University and Izmir S.B.U Tepecik Training and Research Hospital.
Main Results:
- Children with AD exhibited significantly higher platelet counts compared to the control group.
- Mean platelet to neutrophil ratio and mean absolute lymphocyte count were also significantly elevated in the AD group.
- Conversely, the mean absolute neutrophil count was significantly lower in children with AD.
Conclusions:
- Elevated platelet counts may serve as a potential biomarker for atopic dermatitis in children.
- The observed decrease in the neutrophil to lymphocyte ratio in AD patients warrants further investigation.
- While MPV did not show a significant difference, other platelet-related parameters indicate their involvement in AD pathogenesis.
Background:
It is known that platelets play an important role in inflammatory diseases. Atopic dermatitis (AD) is a chronic, itchy, recurrent inflammatory skin disease that affects 2%-30% of the population, especially in childhood.
Aims:
We investigated the role of platelet count and mean platelet volume (MPV) as biomarkers in children with AD.
Methods:
This cross-sectional retrospective study examined the medical reports of patients who were referred to the Pediatric Allergy and Immunology Outpatient Clinic of the Medical Faculty Hospital, Istanbul Biruni University and the Pediatric Immunology and Allergy Diseases Outpatient Clinics of the Izmir S.B.U Tepecik Training and Research Hospital, for AD. A total of 167 children with AD and 170 healthy children were included in the study.
Results:
Among all participants, 36.5% (n = 61) and 31.8% (n = 54) were female in the patient and control groups, respectively. The mean age was 2.8 ± 2.8 and 3.3 ± 2.5 years in the patient and control groups, respectively. MPV was statistically significantly higher in the patient group than in the control group (P =0.003). Mean platelet to neutrophil ratio and mean absolute lymphocyte count values were significantly higher in the patient group (P <.0001 for both values). However, the mean absolute neutrophil count was lower in the patient group than in the control group and it was considered statistically significant (P <.0001).
Conclusion:
In conclusion, we found significantly higher platelet counts in patients with AD. The decrease in the neutrophil to lymphocyte ratio rate was remarkable. However, there was no significant difference in the MPV values between the patient and control groups.
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