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Identification of Important Genes Associated with the Development of Atherosclerosis

Stanislav Kotlyarov1

  • 1Department of Nursing, Ryazan State Medical University Named After Academician I.P. Pavlov, Russian Federation.

Current Gene Therapy
|March 31, 2023
PubMed

Insights

Atherosclerosis, a complex vascular disease, involves lipid metabolism, inflammation, and hemodynamics. Understanding genetic factors and their interplay with these mechanisms is key for improved diagnosis and patient management.

Area of Science:

  • Cardiovascular Science
  • Pathophysiology
  • Genetics

Background:

  • Atherosclerosis is a leading cause of disability and mortality.
  • It is a complex, long-term vascular disease.
  • Key mechanisms include lipid metabolism disorders, inflammation, and altered hemodynamics.

Purpose of the Study:

  • To explore the multifaceted mechanisms of atherogenesis.
  • To investigate the role of genetic and epigenetic factors in atherosclerosis.
  • To understand the interrelations between lipid metabolism, inflammation, and hemodynamics.

Main Methods:

  • Review of current scientific evidence on atherogenesis.
  • Analysis of genetic and epigenetic influences.
  • Examination of the interplay between hemodynamic changes, lipid metabolism, and inflammation.

Main Results:

  • Evidence highlights the significant role of genetic and epigenetic factors in atherosclerosis predisposition.
  • Lipid metabolism, inflammation, and hemodynamics are interconnected mechanisms in atherogenesis.
  • These factors influence the development and clinical outcomes of the disease.

Conclusions:

  • Further research into these interconnected mechanisms is crucial.
  • Improved understanding can enhance diagnostic and therapeutic strategies for atherosclerosis patients.

Keywords:
Atherosclerosisgeneshemodynamicsinflammationlipid metabolismnon-coding RNAs.regulation

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