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Hematological Incidies May Predict Oxidative Stress in Patients with ST-segment Elevation Myocardial Infarction
Belma Kalayc1, Ayse Ceylan Hamamc O Lu2, S Leyman Kalayc3
1Zonguldak Bulent Ecevit University, School of Medicine, Department of Cardiology, Zonguldak, T��rkiye.
Insights
Certain red blood cell indices, including mean corpuscular volume and mean corpuscular hemoglobin, can predict oxidative stress in patients experiencing ST-segment elevation myocardial infarction.
Area of Science:
- Cardiology
- Hematology
- Biochemistry
Background:
- Oxidative stress is a key factor in atherosclerosis and acute coronary syndromes.
- Understanding biomarkers for oxidative stress in myocardial infarction is crucial for patient management.
Purpose of the Study:
- To investigate the association between hemogram indices and oxidative stress markers in ST-segment elevation myocardial infarction (STEMI) patients.
- To determine if routine blood count parameters can serve as predictors of oxidative stress in STEMI.
Main Methods:
- A prospective, cross-sectional study involving 61 STEMI patients.
- Measurement of 15 hemogram indices and oxidative stress parameters (total oxidative status, total antioxidant status, oxidative stress index) from peripheral blood samples before coronary angiography.
- Statistical analysis including correlation and receiver operating characteristic (ROC) analysis.
Main Results:
- Mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) showed significant negative correlations with total oxidative status (TOS) and oxidative stress index (OSI).
- Red cell distribution width (RDW) demonstrated significant positive correlation with TOS and OSI.
- ROC analysis indicated that MCV, MCH, and RDW are effective predictors of TOS and OSI in STEMI patients.
Conclusions:
- MCV, MCH, and RDW levels are valuable predictors of oxidative stress in patients with STEMI.
- These hemogram indices offer a potential non-invasive method for assessing oxidative stress in acute myocardial infarction settings.
Objective:
Oxidative stress is closely related to the development of atherosclerosis and acute coronary syndromes. In this study, we aimed to examine the relationship between hemogram indices and oxidative stress parameters in patients with ST-segment elevation myocardial infarction.
Methods:
A single-centered, prospective, and cross-sectional study was performed in 61 patients with ST-segment elevation myocardial infarction. Before coronary angiography, in the blood samples taken from the peripheral vein, hemogram indices and oxidative stress parameters such as total oxidative status, total antioxidant status, and oxidative stress index were examined. We examined a total of 15 hemogram indices.
Results:
Most of the study patients were male (78%), and the mean age was 59.3 �� 12.2 years. Mean corpuscular volume value was found to be negatively and moderately signi���cantly correlated with total oxidative status and oxidative stress index values (r = ���0.438, r = ���0.490, P <��0.001). A negative and moderate signi���cant correlation was found between mean corpuscular hemoglobin and total oxidative status and oxidative stress index values (r = ���0.487, r = ���0.433, P < 0.001). Red cell distribution width value was found to be positively and moderately correlated with total oxidative status (r = 0.537, P < 0.001). Red cell distribution width was also found to be moderately and statistically signi���cantly correlated with oxidative stress index value (r = 0.410, P = 0.001). In receiver operating characteristic analysis, mean corpuscular volume, mean corpuscular hemoglobin, and red cell distribution width levels have been successful in predicting total oxidative status and oxidative stress index.
Conclusions:
We conclude that mean corpuscular volume, mean corpuscular hemoglobin, and red cell distribution width levels predict oxidative stress in patients with ST-segment elevation myocardial infarction.
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