Related Experiment Video
Updated: Aug 4, 2025
09:44
ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
Published on: January 3, 2025
541
The circadian neutrophil, inside-out
Samuel Ovadia1, Alaz Özcan1, Andrés Hidalgo1,2
1Department of Immunobiology and Program of Vascular Biology and Therapeutics, Yale University, 10 Amistad Street, New Haven, CT 06519, United States.
Journal of Leukocyte Biology
|March 31, 2023
Summary
The body's internal clock influences immune cells like neutrophils. This review explores how daily rhythms control neutrophil function and suggests new research areas in circadian immunity.
Area of Science:
- Immunology
- Chronobiology
- Cellular Physiology
Background:
- The circadian clock regulates numerous physiological processes, notably immune and inflammatory responses.
- Neutrophils, critical immune cells, are increasingly recognized as being under circadian control.
- Understanding diurnal variations in neutrophil function is key to comprehending immune system dynamics.
Conclusions:
- Circadian rhythms play a crucial role in regulating neutrophil function, impacting immunity and homeostasis.
- Further investigation into areas like neutrophil metabolism, tissue clock interactions, and topological influences is warranted.
- This review highlights promising avenues for future research at the intersection of circadian biology and immunology.
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