Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.3K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.3K
Pigmentation01:19

Pigmentation

2.5K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

12.3K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.3K
Cancer02:18

Cancer

49.0K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
49.0K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative PD-1-inhibition in melanoma patients - a retrospective analysis from eight German skin cancer centers.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Nemolizumab for Pruritus Control in Cutaneous T-Cell Lymphoma: A Case Series.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Complete Regression of bilateral Choroidal Metastases secondary to a Cutaneous Melanoma under Immunotherapy.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Timing of sentinel lymph node biopsy in patients with Merkel cell carcinoma: real-world data from a multicentre analysis performed in North Rhine-Westphalia, Germany.

European journal of dermatology : EJD·2026
Same author

Elevated C-Reactive Protein as a Potential Biomarker for Neurological Adverse Events in Immune Checkpoint Inhibitor Therapy: A Prospective Cohort Study.

Oncology research·2026
Same author

General health versus tumor stage: determinants of survival in Merkel cell carcinoma assessed by sentinel lymph node biopsy.

Journal of cancer research and clinical oncology·2026
Same journal

Repositioning Non-Ablative Fractional Lasers - Molecular and Histological Insights from a scoping review.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Infusion-site reactions to foslevodopa/foscarbidopa in Parkinson's disease.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Tranexamic Acid-Soaked Intranasal Packing for Postoperative Bleeding After Nasal Interpolation Flap Repair.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Monoclonal gammopathy of dermatological significance: non-amyloid paraprotein deposits with light and heavy chains.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Papular epidermal nevus with "skyline" basal cell layer: Clinical clues from a three-member family.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

A single-center prospective observational study evaluating the efficacy and safety of tirbanibulin 1% in actinic keratoses in immunosuppressed patients: the ESTIMATE study.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
See all related articles

Related Experiment Video

Updated: Aug 4, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

15.9K

Melanom.

Selma Ugurel1, Ralf Gutzmer2

  • 1Department of Dermatology, Venereology and Allergology, University Hospital Essen.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|March 31, 2023
PubMed
Summary
This summary is machine-generated.

This review covers melanoma, a dangerous skin cancer. It highlights new treatments like BRAF-targeted therapy and immune checkpoint inhibitors, focusing on advanced and adjuvant therapies.

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.8K
A Melanoma Patient-Derived Xenograft Model
07:07

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

12.5K

Related Experiment Videos

Last Updated: Aug 4, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

15.9K
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.8K
A Melanoma Patient-Derived Xenograft Model
07:07

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

12.5K

Area of Science:

  • Oncology
  • Dermatology
  • Cancer Research

Background:

  • Melanoma, or "black cancer of the skin," is an aggressive skin tumor originating from melanocytes.
  • It is characterized by invasive growth and early metastasis via lymphatic and blood systems.
  • Risk factors include UV radiation, fair skin, atypical nevi, and family history.

Purpose of the Study:

  • To provide an overview of current clinical and scientific focus areas in melanoma.
  • To report on new developments in melanoma diagnostics and therapeutics.
  • To highlight advancements in systemic therapies for unresectable melanoma and adjuvant treatments.

Main Methods:

  • Review of current literature on melanoma.
  • Focus on guideline-based diagnosis and therapy.
  • Discussion of systemic treatments including BRAF-targeted therapy and PD-1-based immune checkpoint therapy.

Main Results:

  • Complete excision with adequate safety margins is crucial for primary tumors.
  • BRAF-targeted therapy and PD-1-based immune checkpoint therapy are key systemic treatments.
  • New therapeutic regimens for unresectable melanoma and adjuvant treatments are under investigation.

Conclusions:

  • Guideline-based diagnosis and therapy are critical for melanoma patient outcomes.
  • Significant advancements are being made in systemic and adjuvant melanoma treatments.
  • Ongoing research focuses on novel diagnostic and therapeutic strategies for melanoma.