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Related Experiment Video

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A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion
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Rethinking recovery in adolescent concussions: Network-level functional connectivity alterations associated with

Jewel E Crasta1, Mary Beth Nebel2, Adrian Svingos2

  • 1Occupational Therapy Division, The Ohio State University, Columbus, Ohio, USA.

Human Brain Mapping
|March 31, 2023
PubMed
Summary

Adolescents clinically recovered from concussion show subtle motor deficits. Altered brain connectivity, particularly involving the default mode network, is linked to these persistent motor impairments.

Keywords:
concussiondefault mode networkdorsal attention networkfunctional connectivitymotor function

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Area of Science:

  • Neuroscience
  • Pediatric Neurology
  • Sports Medicine

Background:

  • Subtle motor impairments persist in adolescents even after clinical recovery from concussion.
  • Understanding the brain-behavior relationships of these persistent deficits is crucial for long-term outcomes.
  • Limited research exists on the neurophysiological underpinnings of motor deficits post-concussion recovery.

Purpose of the Study:

  • To investigate the relationship between subtle motor performance and brain functional connectivity in adolescents after concussion.
  • To explore if altered functional connectivity underlies persistent motor deficits in clinically recovered adolescents.

Main Methods:

  • Utilized the Physical and Neurologic Examination of Subtle Signs (PANESS) to assess motor performance.
  • Employed resting-state functional magnetic resonance imaging (rsfMRI) to measure functional connectivity.
  • Compared 27 clinically recovered adolescents with 29 typically developing controls (aged 10-17).

Main Results:

  • Adolescents recovered from concussion exhibited greater subtle motor deficits on the PANESS compared to controls.
  • Increased functional connectivity was observed between the default mode network (DMN) and the left lateral premotor cortex.
  • DMN-premotor cortex connectivity correlated with PANESS scores, indicating a link between connectivity and motor abnormalities.

Conclusions:

  • Altered brain functional connectivity may explain persistent subtle motor deficits in adolescents post-concussion.
  • Functional connectivity alterations, especially within the DMN, warrant further investigation as potential biomarkers.
  • Additional research is needed to determine the long-term clinical significance of these findings.