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Updated: Aug 4, 2025

Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Health registries as research tools: a review of methodological key issues
Sissel Toft Sørensen1,2, Frederik Pagh Kristensen1,2, Frederikke Schønfeldt Troelsen1,2
1Department of Clinical Epidemiology, Aarhus University Hospital.
Abstract:
Health registries provide opportunities for conducting large-scale, population-based studies, but attention must be devoted to their specific limitations. Herein, we describe potential limitations that may affect the validity of registry-based research. Our review includes descriptions of 1) populations, 2) variables, 3) medical coding systems for medical information and 4) selected key methodological challenges. Knowledge of such factors and epidemiological study designs in general is likely to increase the quality of registry-based research and reduce potential biases.
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