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Related Experiment Videos

Steroids, aspirin, and inflammation.

E Katler, G Weissmann

    Inflammation
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Corticosteroids reduce inflammation by inhibiting phagocytic cells, but also impair their ability to kill microbes. This mechanism explains how glucocorticoids reduce inflammation while allowing infections to worsen.

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    Area of Science:

    • Immunology
    • Pharmacology
    • Cell Biology

    Background:

    • Adrenal corticosteroids are known to suppress inflammation and compromise host defenses.
    • Recent advances in understanding inflammation and phagocytic cell biochemistry offer new insights into steroid action.

    Purpose of the Study:

    • To elucidate the mechanism of steroid action on phagocytic cells during inflammation.
    • To explain how corticosteroids alleviate inflammation while potentially increasing susceptibility to infection.

    Main Methods:

    • In vitro and in vivo experiments were conducted.
    • The study analyzed the effects of pharmacologic doses of steroids on various stages of phagocytic-micro-organism interaction.
    • Biochemical pathways including superoxide production and prostaglandin synthesis were investigated.

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    Main Results:

    • Corticosteroids inhibit multiple steps of phagocytic-micro-organism interaction, including chemotaxis, phagocytosis, and degranulation.
    • Steroids alter postphagocytic events like superoxide and hydrogen peroxide production, and prostaglandin/thromboxane synthesis.
    • Unlike nonsteroidal anti-inflammatory agents, corticosteroids impair the killing of microorganisms by inhibiting superoxide production and lysosomal hydrolase release.

    Conclusions:

    • Pharmacologic doses of corticosteroids interfere with the microbicidal activity of phagocytic cells.
    • Glucocorticoids alleviate inflammation by inhibiting inflammatory mediators and phagocytic cell functions.
    • The impairment of microbial killing by corticosteroids explains their ability to reduce inflammation alongside increased susceptibility to infections.