Lorlatinib for ALK-fused, infant-type hemispheric glioma with lung metastasis: a case report
Mingyao Lai1, Shaoqun Li1, Hainan Li2
1Department of Neuro-Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou, 510515, China.
Insights
A rare infant-type hemispheric glioma with lung metastasis showed a complete response to lorlatinib. This highlights the effectiveness of targeted therapy for ALK-fused pediatric gliomas.
Area of Science:
- Neuro-oncology
- Pediatric oncology
- Molecular targeted therapy
Background:
- Infant-type hemispheric glioma is a distinct subtype of pediatric high-grade glioma with unique treatment challenges.
- While survival is better than other high-grade gliomas, effective therapeutic strategies remain an area of active research.
Observation:
- A case of infant-type hemispheric glioma with QKI-ALK fusion and lung metastasis was reported.
- The patient achieved a complete clinical response following treatment with lorlatinib.
Findings:
- The QKI-ALK fusion was identified as a key molecular driver in this pediatric glioma case.
- Lorlatinib demonstrated significant efficacy in treating both the primary tumor and its metastatic spread.
Implications:
- This case underscores the critical role of molecularly targeted treatments for ALK-fused gliomas.
- Lorlatinib presents a promising therapeutic option, potentially complementing traditional treatments for primary and metastatic ALK-fusion-positive gliomas in infants.
Abstract:
Infant-type hemispheric glioma, a new subtype of pediatric high-grade glioma, arises in the cerebral hemispheres. Despite better survival outcomes, the treatment of infant-type hemispheric glioma is still facing challenges. Here, we reported a case of QKI-ALK fusion, infant-type hemispheric glioma with lung metastasis who achieved a complete clinical response after lorlatinib treatment. This typical case demonstrated the importance of appropriate molecularly targeted treatments in ALK-fused tumors, and lorlatinib may serve as an effective complement to conventional chemotherapy and radiotherapy in primary glioma harboring ALK fusions and its metastasis.
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