Related Experiment Video

Updated: Aug 4, 2025

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
07:40

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

1.2K

Rosuvastatin promotes survival of random skin flaps through AMPK-mTOR pathway-induced autophagy

Hantao Ye1, Feida Li1, Yang Shen1

  • 1Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.

International Immunopharmacology
|March 31, 2023
PubMed

Insights

Rosuvastatin, a plant-derived flavonoid, enhances random skin flap survival by promoting angiogenesis and autophagy while reducing pyroptosis and oxidative stress. This study uncovers its therapeutic potential in plastic surgery.

Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Plastic Surgery

Background:

  • Random skin flaps are crucial in plastic surgery but are prone to necrosis from ischemia-reperfusion injury.
  • Flap survival is a significant clinical challenge, necessitating novel therapeutic strategies.
  • Rosuvastatin, a flavonoid, has shown potential in aiding flap survival.

Purpose of the Study:

  • To investigate the underlying mechanisms by which rosuvastatin improves random skin flap survival.
  • To elucidate the role of autophagy, angiogenesis, pyroptosis, and oxidative stress in rosuvastatin's protective effects.
  • To evaluate rosuvastatin's efficacy in a preclinical model.

Main Methods:

  • Experimental mice were divided into control, rosuvastatin, and 3-methyladenine (3MA) plus rosuvastatin groups.
  • Histological and protein analyses were performed to assess angiogenesis, pyroptosis, oxidative stress, and autophagy.
  • Tissue edema was also evaluated to gauge treatment effects.

Main Results:

  • Rosuvastatin significantly improved random skin flap survival and reduced tissue edema.
  • The treatment promoted angiogenesis and induced autophagy.
  • Rosuvastatin markedly reduced pyroptosis and oxidative stress.

Conclusions:

  • Rosuvastatin enhances random skin flap survival by promoting angiogenesis and autophagy.
  • The protective effects are mediated by the reduction of pyroptosis and oxidative stress through autophagy induction.
  • Rosuvastatin represents a promising therapeutic agent for improving outcomes in plastic surgery involving skin flaps.
Keywords:
AutophagyPyroptosisRandom skin flapsRosuvastatin

More Related Videos

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

18.8K
siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells09:10

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

Published on: October 28, 2019

7.3K

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.4K
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
3.5K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.7K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
6.6K