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Related Experiment Videos

The LMP antigens: a stable MHC-controlled multisubunit protein complex.

J J Monaco, H O McDevitt

    Human Immunology
    |April 1, 1986
    PubMed
    Summary

    The murine MHC encodes a large, intracellular protein complex (LMP) distinct from known antigens. Its function remains unknown, but its subunit genetics and potential human homolog offer avenues for research.

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    Area of Science:

    • Immunogenetics
    • Molecular Biology
    • Protein Biochemistry

    Background:

    • The murine Major Histocompatibility Complex (MHC) encodes Class I, II, and III antigens.
    • The MHC also controls a large, intracellular protein complex (LMP) with an undetermined function.
    • LMP is composed of multiple low molecular weight polypeptide subunits, biochemically and genetically distinct from MHC antigens.

    Purpose of the Study:

    • To review the biochemistry, serology, and genetics of LMP antigens.
    • To explore the potential biological function of the LMP complex.
    • To investigate the mapping of LMP subunits within the murine genome.

    Main Methods:

    • Biochemical analysis of LMP subunit composition.
    • Serological characterization of LMP antigens.
    • Genetic mapping of LMP polymorphisms within the H-2 complex.

    Main Results:

    • Two LMP subunits exhibit electrophoretic polymorphism in inbred mice.
    • These polymorphisms are located within the H-2 complex, between H-2K and I-A subregions.
    • The genetic mapping of other LMP subunits remains incomplete, suggesting potential extragenomic encoding.

    Conclusions:

    • The LMP complex represents a novel MHC-controlled entity with distinct biochemical and genetic properties.
    • Further research is needed to elucidate the function of LMP and its potential role in cellular processes.
    • A similar complex exists in human cells, warranting investigation into its linkage with HLA.

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