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Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
Published on: January 7, 2019
3D nanofiber sponge with dimethyloxaloglycine-loaded Prussian blue analogue microspheres to promote wound healing
Jiatian Chen1,2, Zihang Huang1, Xiaotong Wu1
1Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, People's Republic of China.
Abstract:
The fabrication of functional wound dressing for effective hemostasis, anti-inflammation as well as angiogenesis is of vital importance. In this paper, a three-dimensional (3D) nanofiber sponge with dimethyloxaloglycine (DMOG) loaded mesoporous spheres of derivatives of Prussian blue analogues (PBAs) was prepared (3D-PBAFeCo-DMOG). The nanostructure, composition, and mechanical properties of 3D-PBAFeCo-DMOG were characterized, showing regular nanostructure and good mechanical property. The behavior ofin vitrodrug release showed the DMOG could achieve long-term and stable release by encapsulating in PBAFeComicrospheres and nanofibers.In vitrocoagulation experiments showed that 3D-PBAFeCo-DMOG had effective hemostasis and clotting capacities. In addition, the antioxidant capacity and cell compatibility of 3D-PBAFeCo-DMOG were confirmed. These results indicate that 3D-PBAFeCo-DMOG nanofiber sponge, as a controlled drug release system, may provide a new strategy for promoting angiogenesis and wound healing for clinical applications.
