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Published on: December 31, 2017
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Cerebral abscesses with odontogenic origin: a population-based cohort study.
Frederik V B Jespersen1,2, Signe U-B Hansen1, Simon S Jensen1,2
1Cariology and Endodontics, Section of Clinical Oral Microbiology, Department of Odontology, University of Copenhagen, Nørre Allé 20, 2200, Copenhagen, Denmark.
Clinical Oral Investigations
|March 31, 2023
Summary
Cerebral abscesses (CA) of dental origin are increasing. This study found Type two diabetes and Streptococcus anginosus group bacteria were more common in patients with odontogenic CA, highlighting oral health importance.
Area of Science:
- Neurology
- Infectious Diseases
- Dentistry
Background:
- Cerebral abscesses (CA) of odontogenic origin are increasingly recognized.
- Many CA cases lack clear etiologic characterization.
- Understanding odontogenic CA is crucial for diagnosis and treatment.
Purpose of the Study:
- To identify and characterize CA patients with a potential odontogenic origin.
- To analyze microbiologic, radiographic, and clinical data for odontogenic CA indicators.
Main Methods:
- Population-based cohort study with retrospective and prospective data.
- Analysis of panoramic radiographs (PRs) and computed tomography (CT) scans.
- Defined criteria for odontogenic CA: exclusive oral infection, oral microbes in brain pus, and oral pathology evidence.
Main Results:
- 25 out of 44 patients (57%) had CA of likely odontogenic origin.
- Type two diabetes (T2D) was significantly overrepresented (p=0.014).
- Streptococcus anginosus group (SAG) microorganisms were overrepresented (p<0.01).
Conclusions:
- Odontogenic infections contribute more to CA than previously thought.
- T2D is a risk factor for odontogenic CA.
- Isolation of SAG suggests odontogenic or sinus origin for CA.
Keywords:
Brain abscessDental infection controlMicrobiologyOral healthOral pathologyPanoramic radiography
