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Seizure control during spontaneous battery failure with responsive neurostimulation
Ryan Ward1, Alexandra C Vallera1, Irfan Ali1,2
1Department of Neurology, Baylor College of Medicine, Houston, Texas, 77030, USA.
Summary
Responsive neurostimulation (RNS) benefits may persist after battery failure, suggesting lasting neuroplasticity. Most patients experienced no change or fewer seizures when RNS was inactive.
Area of Science:
- Neurology
- Neuroscience
- Biomedical Engineering
Background:
- Responsive neurostimulation (RNS) is an effective epilepsy treatment.
- Understanding RNS's long-term effects, independent of continuous stimulation, is crucial.
Purpose of the Study:
- To investigate seizure control during RNS battery failure.
- To determine if RNS benefits persist without active neurostimulation.
Main Methods:
- Retrospective chart review and telephone surveys of patients experiencing RNS battery depletion.
- Assessed seizure frequency changes during periods without device function.
Main Results:
- Eight of ten patients with RNS battery failure participated.
- Mean battery failure duration was 36 days.
- Most patients (6/8) reported no increase in seizure frequency; two reported an increase.
Conclusions:
- RNS therapy may induce persistent neuroplastic changes.
- The therapeutic effects of RNS may extend beyond the period of active stimulation.
