Peptides for trans-blood-brain barrier delivery

Area of Science:

• Neuroscience
• Radiopharmaceutical Science
• Drug Delivery

Background:

• Efficient transport of agents across the blood-brain barrier (BBB) is critical for central nervous system (CNS) therapies.
• Radiopharmaceuticals for CNS targeting face significant delivery challenges.
• Peptides are emerging as key facilitators for trans-BBB delivery.

Approach:

• This review surveys peptides that penetrate the BBB.
• It highlights the diverse cargos successfully delivered into the CNS using these peptides.
• Recent advancements in cell-penetrating peptides (CPPs) are discussed.

Key Points:

• BBB-penetrating peptides are reviewed for their role in CNS drug delivery.
• Cell-penetrating peptides (CPPs) show potential for next-generation delivery systems.
• Various cargos have been delivered into the CNS using peptide carriers.

Conclusions:

• Peptides are effective agents for trans-BBB delivery of CNS-targeted agents.
• New CPP developments offer enhanced opportunities for CNS drug delivery.
• Peptides are poised for integration with diagnostic and therapeutic radiopharmaceuticals for improved CNS targeting.