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Benzylpenicillin-induced neutropenia
The Journal of Antimicrobial Chemotherapy
|February 1, 1986
Summary
Neutropenia can occur with parenteral benzylpenicillin. This study suggests freshly prepared benzylpenicillin injections, not just stored solutions, may also cause this serious complication.
Area of Science:
- Pharmacology
- Hematology
- Infectious Diseases
Background:
- Parenteral benzylpenicillin is used for bacterial infections.
- Neutropenia, a low white blood cell count, is a known risk.
- This complication is often associated with stored penicillin solutions.
Observation:
- Three cases of neutropenia following fresh benzylpenicillin bolus injections are presented.
- A literature review identified 25 additional cases.
Findings:
- Freshly prepared benzylpenicillin, administered via bolus injection, can induce neutropenia.
- The risk may not be limited to stored penicillin infusion solutions.
Implications:
- Clinicians should be aware of neutropenia risk with both fresh and stored benzylpenicillin preparations.
- Further investigation into the mechanisms and incidence of benzylpenicillin-induced neutropenia is warranted.