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Updated: Aug 4, 2025
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Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
Published on: December 17, 2014
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Stem cells for neonatal brain injury - Lessons from the bench
So Yoon Ahn1, Yun Sil Chang2, Won Soon Park2
1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South Korea; Cell and Gene Therapy Institute, Samsung Medical Center, Seoul 06351, South Korea.
Seminars in Perinatology
|April 1, 2023
Summary
Mesenchymal stem cells (MSCs) show promise for treating neonatal brain injury. This review explores preclinical research on MSCs transplantation for conditions like intraventricular hemorrhage and hypoxic ischemic encephalopathy.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Pediatric Neurology
Background:
- Neonatal brain injury, including intraventricular hemorrhage and hypoxic ischemic encephalopathy, leads to significant mortality and morbidity.
- Current treatments for neonatal brain injury are limited, highlighting the need for novel therapeutic approaches.
Approach:
- This review synthesizes preclinical research on stem cell therapy for neonatal brain injury.
- Focuses on mesenchymal stem cells (MSCs) and their neuroprotective mechanisms.
- Examines critical factors for MSCs transplantation: cell source, route, timing, and dosage.
Key Points:
- Mesenchymal stem cells (MSCs) exhibit pleiotropic neuroprotective effects.
- Preclinical evidence suggests MSCs transplantation is a potential therapy for neonatal brain injury.
- Understanding MSCs' mechanisms and optimizing transplantation parameters are crucial.
Conclusions:
- Stem cell therapy, particularly using mesenchymal stem cells (MSCs), offers a promising new avenue for treating neonatal brain injury.
- Further research into optimizing MSCs transplantation is essential for clinical translation.
Keywords:
Cerebral intraventricular hemorrhageHypoxia-ischemia, BrainInfantMesenchymal stem cellsNeuroprotectionNewbornMore Related Videos
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