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Published on: October 23, 2014
An update on the role of Hippo signaling pathway in ischemia-associated central nervous system diseases
Xuan Wei1, Guangshan Huang1, Jiyong Liu2
1Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese Medicine and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
Insights
Cerebral ischemia causes significant neurological damage. Targeting the Hippo signaling pathway offers a promising therapeutic strategy for treating ischemia-associated central nervous system diseases like stroke and Alzheimer's.
Area of Science:
- Neuroscience
- Molecular Biology
- Cell Biology
Background:
- Cerebral ischemia is a leading cause of death and disability worldwide, triggering complex molecular and cellular damage in the central nervous system (CNS).
- Neurological disorders such as ischemic stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) are linked to these ischemic pathologies.
- Current treatments for these CNS diseases are limited in their ability to specifically mitigate ischemic damage.
Purpose of the Study:
- To explore the role of the Hippo signaling pathway in the pathogenesis of ischemia-associated CNS disorders.
- To review recent advancements in understanding the Hippo pathway's molecular mechanisms.
- To highlight the therapeutic potential of targeting the Hippo pathway for treating CNS diseases linked to ischemia.
Main Methods:
- Literature review of recent studies on the Hippo signaling pathway and its involvement in CNS diseases.
- Analysis of the molecular components and functions of the Hippo pathway (MST1/2, LATS1/2, YAP/TAZ).
- Discussion of the pathway's role in processes like oxidative stress, inflammation, blood-brain barrier integrity, mitochondrial dysfunction, and neuronal death.
Main Results:
- The Hippo signaling pathway regulates critical cellular processes including division, survival, and differentiation, and is involved in nervous system development.
- Emerging evidence indicates the Hippo pathway's participation in the pathophysiology of ischemic stroke, AD, and PD.
- The pathway is implicated in key pathological mechanisms such as oxidative stress, neuroinflammation, blood-brain barrier disruption, and neuronal apoptosis.
Conclusions:
- Understanding the Hippo signaling pathway's molecular underpinnings is essential for developing novel therapeutic targets.
- Targeting the Hippo signaling pathway presents a promising strategy for mitigating damage in ischemia-associated CNS diseases.
- Further research into the Hippo pathway could lead to effective treatments for debilitating neurological conditions.
Abstract:
The most frequent reason of morbidity and mortality in the world, cerebral ischemia sets off a chain of molecular and cellular pathologies that associated with some central nervous system (CNS) disorders mainly including ischemic stroke, Alzheimer's disease (AD), Parkinson's disease (PD), epilepsy and other CNS diseases. In recent times, despite significant advancements in the treatment of the pathological processes underlying various neurological illnesses, effective therapeutic approaches that are specifically targeted to minimizing the damage of such diseases remain absent. Hippo signaling pathway, characterized by enzyme linked reactions between MSTI/2, LAST1/2, and YAP or TAZ proteins, controls cell division, survival, and differentiation, as well as being engaged in a variety of biological activities, such as the development and transformation of the nervous system. Recently, accumulating studies demonstrated that Hippo pathway takes part in the processes of ischemic stroke, AD, PD, etc., including but not limited to oxidative stress, inflammatory response, blood-brain barrier damage, mitochondrial disorders, and neural cells death. Thus, it's crucial to understand the molecular basis of the Hippo signaling pathway for determining potential new therapeutic targets against ischemia-associated CNS diseases. Here, we discuss latest advances in the deciphering of the Hippo signaling pathway and highlight the therapeutic potential of targeting the pathway in treating ischemia-associated CNS diseases.
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