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Effect of Famotidine on COVID-19: Killing Virus or Opposing ARDS?
Mahnaz Sadat Hosseini1, Effat Davoudi-Monfared1, Farhad Najmeddin1
1Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Porsina St., Tehran, Tehran Province, Iran.
Abstract:
Since the first detection of SARS-CoV-2 in China, COVID-19 (Corona Virus Disease 2019) has taken the lives of more than six million people. Although some antivirals seem proper for treatment, the investigation of finding the best therapeutic approach for COVID-19 is still continuing. Some observational research showed that famotidine has promising effects in addition to its acid-suppressing characteristics in the treatment of COVID-19. The definite viricidal effect of famotidine is not established. Opposing acute respiratory distress syndrome (ARDS) can be proposed as a probable mechanism for the action of famotidine, due to its inhibitory effect on histamine release, inhibition of transmembrane protease serine S (TMPRSS) and stabilizing glycocalyx. These hypotheses should be under investigation in the future.
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